Research Reproducibility:

Innovative Solutions to Drive Quality

The 2016 Summit—Research Reproducibility:  Innovative Solutions to Drive Qualitywelcomed premiere life science thought leaders as speakers and panelists. We were joined in the conversation by top scientists and policy makers from NIH, science societies, foundations, journals and industry, and GBSI’s challenge to the bio-research community, Reproducibility2020 was introduced.  

Reproducibility2020 outlines solutions in the following areas: 1) improved validation and standardization of biological reagents; 2) better tools and technologies to expand open access for reporting and sharing protocols and data; and 3) increased training that emphasizes rigorous study design and practice.

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Speakers

Keynote Speaker

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Judith Kimble, Ph.D.

Judith Kimble is Vilas Professor in the Department of Biochemistry at the University of Wisconsin-Madison and an Investigator in the Howard Hughes Medical Institute. Her undergraduate degree is from the University of California, Berkeley and her Ph. D. from the University of Colorado, Boulder. She was a postdoctoral fellow at the MRC Laboratory of Molecular Biology in Cambridge, England and joined the faculty at the University of Wisconsin-Madison in 1983, where she has been since. Her honors include election to the National Academy of Sciences in 1995, selection as a Vilas Professor in 2001, one of the highest honors at the University of Wisconsin-Madison, and selection as chair of the President’s Committee on National Medal of Science.

Kimble has served the biomedical research community in numerous capacities. She serves on the NRC Committee for Science, Engineering and Public Policy (COSEPUP), the NRC Board of Life Sciences and the Steering Committee for the National Rescuing Biomedical Research Website. Through her work on COSEPUP, she organized a workshop “Rising above the gathering storm: Creating regional innovation environments”. Most recently, she organized a workshop at UW Madison “Rescuing Biomedical Research from its Systemic Flaws: Strategies and Pathways Ahead”, which engaged biomedical researchers across campus, ranging from Ph. D. students and postdocs to deans and emeriti and from basic to clinical scientists.

Moderator

Richard Harris

Richard Harris, NPR News Science Correspondent

Award-winning journalist Richard Harris has reported on a wide range of topics in science, medicine and the environment since he joined NPR in 1986. Currently Harris is on leave from NPR to write a book about rigor and reproducibility in bio-medical science, which will be published by Basic Books.  He is also currently a visiting scholar at Arizona State University.

In early 2014, his focus shifted from an emphasis on climate change and the environment to bio-medical research. Over the course of his career, Harris has been the recipient of many prestigious awards. Those include the American Geophysical Union’s 2013 Presidential Citation for Science and Society. He shared the 2009 National Academy of Sciences Communication Award and was a finalist again in 2011. In 2002, Harris was elected an honorary member of Sigma Xi, the scientific research society. Harris shared a 1995 Peabody Award for investigative reporting on NPR about the tobacco industry. Since 1988, the American Association for the Advancement of Science has honored Harris three times with its science journalism award.

Harris is co-founder of the Washington, D.C. Area Science Writers Association, and is past president of the National Association of Science Writers. He serves on the board of the Council for the Advancement of Science Writing.

Panelists

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Arturo Casadevall, M.D., Ph.D.

Arturo Casadevall, M.D., Ph.D., is Bloomberg Distinguished Professor and Chair of the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.  Previously he served as Director of the Division of Infectious Diseases at Montefiore Medical Center, the University Hospital and Academic Medical Center for Einstein, and as Chair of the Department of Microbiology and Immunology. Dr. Casadevall received both his M.D. and Ph.D. (biochemistry) degrees from New York University. Subsequently, he completed his internship and residency in internal medicine at Bellevue Hospital in New York. He also has subspecialty training in infectious diseases.

Dr. Casadevall is the editor-in-chief of mBio, the first open access general journal of the American Society of Microbiology, and is on the editorial board of several journals including the Journal of Infectious Diseases and the Journal of Experimental Medicine. He has also served in numerous NIH committees including those that drafted the NIAID Strategic Plan and the Blue Ribbon Panel on Biodefense Research.  He served on the National Academy of Sciences panel that reviewed the science on the FBI investigation of the anthrax terror attacks of 2001.  He has also served as a member of the National Science Advisory Board for Biosecurityand currently co-chairs the NIAID Board of Scientific Counselors. In 2008, he was recognized the American Society of Microbiology with the William Hinton Award for mentoring scientists from underrepresented groups.  He has been elected to AAAS Fellowship, the American Society for Clinical Investigation, the American Academy of Microbiology, the American Association of Physicians and the National Academy of Medicine (Institute of Medicine).  Dr. Casadevall was newly appointed a Commissioner to the National Commission on Forensic Science, the United States Department of Justice.

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Amy Elizabeth Herr, Ph.D.

Amy E. Herr received a BS degree in Engineering & Applied Science from the California Institute of Technology and MS and PhD degrees from Stanford University in Mechanical Engineering. She is currently the Lester John & Lynne Dewar Lloyd Distinguished Professor of Bioengineering at the University of California, Berkeley. Prior to joining UC Berkeley, she was a staff member in the Biosystems Research Group at Sandia National Laboratories (Livermore, CA).  Professor Herr has served as Co-Director of the Cold Spring Harbor Laboratory’s Single Cell Analysis summer course, and as both Chair and Vice-chair (2007) of the Gordon Research Conference (GRC) on the Physics & Chemistry of Microfluidics.  Currently, she serves as a Board Member of the Chemical & Biological Microsystems Society (CBMS) and as a standing member of the NIH Nanotechnology Study Section.  She is faculty advisor to the UC Berkeley chapter of the Society of Women Engineers (SWE) and the Graduate Women in Engineering (GWE).

Professor Herr is an elected Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Board member of the Chemical & Biological Microsystems Society (CMBS) which oversees the microTAS conferences, and is on the Advisory Board for the UCSF Rosenman Institute and the journal Analytical Chemistry. She has been recognized by:  the 2015 Georges Guiochon Faculty Fellow from HPLC, the 2012 Young Innovator Award from Analytical Chemistry/CBMS,  the 2012 Ellen Weaver Award from the Association for Women in Science (AWIS, for mentoring), a 2011 NSF CAREER award, a 2010 NIH New Innovator Award, a 2010 Alfred P. Sloan Research Fellowship in chemistry, 2a 010 New Investigator Award in Analytical Chemistry from Eli Lilly & Co., a 2009 Defense Advanced Research Projects Agency (DARPA) Young Faculty Award, a 2009 Hellman Family Faculty Fund Award from UC Berkeley, a 2008 Regents’ Junior Faculty Fellowship from the University of California.  Professor Herr has also been recognized by the 2012 Outstanding Instructor Award in Bioengineering (Bioengineering Honor Society student vote) and a 2007 Outstanding Mentor Award from Sandia National Laboratories.

Joshua LaBaer

Josh LaBaer, M.D., Ph.D.

Josua LaBaer is the Director of the Virginia G. Piper Center for Personalized Diagnostics, the Virginia G. Piper Chair of Personal Medicine and a Professor of Chemistry and Biochemistry at The BioDesign Institute at Arizona State University.  He was formerly the founder and director of the Harvard Institute of Proteomics.

Dr. LaBaer earned his medical degree and a doctorate in biochemistry and biophysics, from the University of California, San Francisco. He is a board certified physician in internal medicine and medical oncology and was an instructor and clinical fellow in medicine at Harvard Medical School. He has contributed more than 120 original research publications, reviews and chapters.

Dr. LaBaer is an associate editor of the Journal of Proteome Research and a member of the editorial boards of Analytical Biochemistry, Current Opinion in Biotechnology, Cancer Biomarkers, Molecular Biosystems, and Clinical Proteomics. He is a member of the National Cancer Institute’s Board of Scientific Advisors and serves as chair of the National Cancer Institute’s Early Detection Research Network Executive Committee and Co-Chair of its Steering Committee.  He is treasurer and president-elect of the U.S. Human Proteome Organization.  He also serves on a number of government and industry scientific advisory boards.

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Brian Nosek, Ph.D.

Brian Nosek received a Ph.D. in from Yale University in 2002 and is a professor in the Department of Psychology at the University of Virginia. In 2007, he received early career awards from the International Social Cognition Network (ISCON) and the Society for the Psychological Study of Social Issues (SPSSI). He co-founded Project Implicit an Internet-based multi-university collaboration of research and education about implicit cognition – thoughts and feelings that exist outside of awareness or control. Nosek investigates the gap between values and practices – such as when behavior is influenced by factors other than one’s intentions and goals. Research applications of this interest are implicit bias, diversity and inclusion, automaticity, social judgment and decision-making, attitudes, beliefs, ideology, morality, identity, memory, and barriers to innovation. Through lectures, training, and consulting, Nosek applies scientific research to improve the alignment between personal and organizational values and practices.

Nosek co-founded and directs the Center for Open Science that operates the Open Science Framework. The COS aims to increase openness, integrity, and reproducibility of scientific research. COS is a non-profit, technology start-up with three primary activities: (1) building and maintaining the Open Science Framework that supports the research workflow and enables transparency, archiving, and pre-registration; (2) building community and shifting incentives such as badges for articles to acknowledge open practices; and, (3) conducting metascience such as estimating the reproducibility of scientific research by conducting large-scale, crowdsourced replication projects.

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Timothy S. Simcoe, Ph.D.

Timothy S. Simcoe is an Associate Professor of Strategy and Innovation at the Boston University Questrom School of Business, and a Faculty Research Fellow at the National Bureau of Economic Research. From 2014 to 2015, he served as a Senior Economist on the President’s Council of Economic Advisers.

Professor Simcoe’s research focuses on standards, innovation and technology policy, intellectual property and corporate strategy. His research has been published in the American Economic Review, Management Science, the RAND Journal of Economics, Organization Science and the Journal of Applied Econometrics. He is an editor at Management Science and the Journal of Industrial Economics. In 2012 served on a National Academy of Sciences Committee to evaluate Intellectual Property Management in Standard-Setting Processes.

Dr. Simcoe holds a B.A. in Applied Mathematics from Harvard, along with an M.A. in Economics and a Ph.D. in Business Administration from the University of California, Berkeley.